• Investigating molecular mechanisms of Healthy aging

    Basic research and systems-level approaches to discover drugs and develop novel strategies to treat age-related pathologies.

  • Our Mission

    Our aim is to determine the molecular mechanism(s) that prolong health during aging, using systems level approaches on human biology, omics, machine learning, C. elegans and mice, in order to develop novel clinical strategies to treat age-related pathologies.

    Global Challenge

    Age-dependent diseases

    By 2030 almost every fourth person will be 65 or older in Switzerland, Europe, and USA. Since old age is the main risk factor for developing cancer, neurodegenerative, cardiovascular, and metabolic diseases, as well as other age-related pathologies, the growing elderly population poses an immense social and financial challenge. [read more] [pdf]

    Strategic Goal

    To identify novel strategies to improve human healthspan.

    Using C. elegans as a pioneering system to model the aging process because of its ease for genetic manipulation, high evolutionary conservation of genes implicated in human diseases, and short lifespan (3 weeks). Importantly, using C. elegans lifespan assays as a read-out for extension of healthspan is a tractable and fast approach for discovering novel mechanisms that confer healthy aging. Several fundamental mechanisms discovered in C. elegans have been shown to delay age-related pathologies in higher organisms, such as mice, and these mechanisms have major implications for humans aging. Hence, by using C. elegans to model the aging process we could rapidly identify strategies to improve human healthspan.

    Research

    Currently, the lab focuses on exploring a novel and exciting mechanism that promotes healthy aging.

    Our recent work has shown that many health- and longevity-promoting interventions re-activate the expression of extracellular matrix (ECM) genes during aging (Ewald et al., Nature 2015, PMID:25517099). This ECM enhancement is required and sufficient for extending the lifespan of C. elegans. Our research efforts are focusing on exploring the mechanism(s) of how prolonged ECM homeostasis promotes healthy aging. [read more] [pdf]

     

    Our core competencies are:

    1. Aging research
    2. Extracellular matrix biology, matrisome, and matreotype
    3. Drug discovery, molecular biology, genetics, systems biology, and neuroscience

    Our technical expertise with using the model organism C. elegans are:

    • Automated lifespan assessment using the lifespan machine.
    • High-throughput screening with genetic manipulations and chemical compounds for aging research.
    • Neuronal plasticity (learning) assays.
    Experimental advantage for using C. elegans
    • No animal safety or ethical issues: For FSVOC. elegans not defined as an animal
    • 60-80% of genes conserved with humans
    • multicellular and eukaryotic
    • C. elegans ages similar to humans, but faster (lifespan of 3 weeks)
    • scalable for high-throughput genetic and drug screens
    • (and because of: Brenner-->worms-->transgenics-->coffee-->biofuel--> future: watch this https://youtu.be/76W7lriuo1o)

    Ziel der Forschungsgruppe

    Lay summary in German

    Wir alle werden älter und mit jedem zusätzlichen Jahr steigt das Risiko für den
    Ausbruch einer altersbedingten Krankheit wie Krebs, Diabetes, Alzheimer oder
    Herzkreislaufprobleme. [weiter lesen] [pdf]

     

    Kapitelauszug über unsere Forschung geschrieben von Alejandra Garcia Lanz (Schülerin der Gewerblich-Industrielle Berufsschule Bern; Vertiefungsarbeit ABU, 7.3.2019)

    [Gestern, heute und morgen - Langlebigkeit.pdf]

     

    Wenn Sie mehr wissen wollen, meine Einführungsvorlesung an der ETH Zürich gibt eine gute Übersicht über unsere Forschung.

    Videolink zur Einführungsvorlesung

    Auf den Link klicken und die Vorlesung: "Molekulare Mechanismen des gesunden Alterns (Collin Ewald)" kommen.

    News Media

    Recent Interviews

    Kann man das Altern verlangsamen? Fadenwürmer im Fokus der Altersforschung. EwaldLab Interview by Patrick Bardelli Galaxus Hintergrund, Sport, Gesundheit. 12.05.2022
    https://www.galaxus.ch/de/page/fadenwuermer-im-fokus-der-altersforschung-23588

     

    Labor Journal: Nur nicht bescheiden sein. 12.05.2022

    Wer als Forscher mit einem Start-up erfolgreich sein will, muss einiges beachten. 

     

    Life Science Get2Gether #LSG2G by #ChristianSoschner
    Episode #69: Prof. Collin Ewald - Molecular Mechanisms of Healthy Ageing

    Feb 26th 2022

    https://youtu.be/7uH3m6spb_g

    #longevity #extracellularmatrix

     

    #Age is just a number. Flipping a genetic switch, even at #old age, can #rejuvenate #elderly worms. Episode 78. January 2022. Start 30min. Interviewed by @DrChrisSmith @nakedscientists.

    https://elifesciences.org/podcast/episode78#1828

    Research Article by Richard Venz et al. @elife.

     

    Live Longer World interview: Dr. Collin Ewald | Collagen Protein & Extracellular Matrix During Aging. January 18th 2022

    https://youtu.be/r1Y5wGSqKWA

     

    Longevity Technology (#Innovation): Increased lifespan? Make mine a double!

    October 29, 2021

    https://www.longevity.technology/increased-lifespan-make-mine-a-double/

     

    Mindset 2021: Bernegger, Marc P.; Gushchina, Julia; Branford, Jason; Rochel, Johan. 30.09.2021

    Mentioning Ewald Lab at 34min 29sec.

    https://oc-vp-distribution04.ethz.ch/mh_default_org/oaipmh-mmp/2ecafd17-6f18-4b65-807e-ec2a406c7946/a2a16b40-7b17-460c-8725-45df2cd5717f/20210921_HGF3_Mindset_2021.mp4

     

    Maximon: the Longevity Company Builder: Clubhouse The Longevity Biotech Show 8.4.2021

    https://youtu.be/QhtXxsBK3oc

     

    «Covidisierung» der Forschung verzögert andere Projekte: Echo der Zeit @SRF2 10.01.2021

    https://www.srf.ch/play/radio/popupaudioplayer?id=b75fdf5c-8108-4966-8047-cd0e651e0830

    Full: https://www.srf.ch/audio/echo-der-zeit/schicksalstage-fuer-italiens-regierung?id=11911208

     

    Gesundes Altern - Fit wie Joe Biden

    Danke für den schön geschrieben Artikel von Alexandra Bröhm @sonntagszeitung und das Interview mit mir über #Gesund ins hohe #Alter- wie Joe Biden. #healthy #aging #extrazelluläreMatrix #ewaldlab @ETH.

    https://www.tagesanzeiger.ch/fit-wie-joe-biden-wie-bleibt-man-im-alter-lange-gesund-704858203320

     

    Altersforschung und Anti-Aging Interview mit Prof. Dr. Collin Ewald

    Ein Altersforscher in Zürich erprobt am Fadenwurm, welche Gene unsere Zellen altern lassen und was Anti-Aging-Medikamente bewirken.

    BR Fernsehen Gut zu wissen | Wissensmagazin. 21.03.2020, 19:00 Uhr.

    Fast-forward to minute 21.

    https://www.br.de/mediathek/video/gut-zu-wissen-wissensmagazin-schutz-gegen-corona-impfstoff-gegen-covid-19-immunsystem-staerken-im-bauernhofkindergarten-altersforschung-und-anti-aging-av:5e73670f4c56f6001308060a

     

    (Also broadcasted by Arte, Wissenschaft, Xenius: Alternsforschung. Our part after 3 min: https://www.arte.tv/de/videos/092139-033-A/xenius-altersforschung/)

     

    Superhighway Of Our Cells: Extracellular Matrix with Prof. Collin Ewald- Ira Pastor, ideaXme longevity and aging ambassador and Founder of Bioquark, interviews Prof. Dr. Collin Ewald, Department of Health Sciences and Technology, at ETH Zurich (The Swiss Federal Institute of Technology in Zurich), Founder of Swiss Society for Aging Research and Vice President Swiss Society for Matrix Biology.

    https://youtu.be/j8_6iBP6hqM

    @IraSamuelPastor

    https://radioideaxme.com/2019/09/10/dr-collin-ewald-ecm/

     

    Dem Alter auf der Spur: Jung bleiben bis ins hohe Alter: Das sagt die Forschung - SRF Kultur

    «Warum altern wir? @sciencezoe sprach mit ETH-Forscher @CollinEwald, der dieses Rätsel mit Hilfe winziger Würmer lösen will.

     

    Alumni Spotlight Graduate Center of the City University of New York

    https://www.gc.cuny.edu/news/science-alumni-spotlight-collin-ewald

     

    Time: As long as you live. TVB News (Hong Kong)

    See starting after 1:34 and 2:28. #EwaldLab

    http://news.tvb.com/programmes/aslongasyouliveii/5becbeb3e60383c70be8f5c9

     

    Who is Who in Medical Research: A compendium of Hochschulmedizin Zurich (1st edition 2017) compiles all the information of nearly 200 research groups at the level of professorships relevant for collaboration in the medical field.

    https://www.hochschulmedizin.uzh.ch/dam/jcr:ae0c5e9b-dbd0-439e-aa49-c4c15476166e/HMZ_WhoIsWho_2017.pdf

     

    Welcome to the (Extracellular) Matrix: An interview with Dr. Collin Ewald - Geroscience

     

    Ep. 3 - Prof. Collin Ewald talks getting old and feeling young - Part 1 | Simplifyd

     

    Ep. 3 - Prof. Collin Ewald talks the cost of Alzheimer's and "mega cancer"- Part 2 | Simplifyd

     

    An almost forgotten pioneer - UNI NOVA

     

    Social Media

    ETH/EPFL Influencer World Ranking

    https://ranking.influencer.world/en/set/eth-epfl

    Collin Ewald (@CollinEwald) (Ranked 16th, 30.09.20)

    TV highlights

    TV Reports

    #Alternsforschung: Ein Bericht über unsere Forschung #EwaldLab @ETH  ausgestrahlt von @SRF

    Nano (8.9.2020). Siehe Link und bitte vorspulen auf 10min 42sec.

    @cyril_statzer @VenzRichard @Alincaro_T @JongsmaE

    https://srf.ch/play/tv/nano/video/nano?urn=urn:srf:video:e2c27d79-b6af-438a-b2ba-f53c9326ab3e

    Recent Science

    Current Research from the Ewald Lab

    If you want to see the latest research coming out of the Ewald lab.

     

    Collin Ewald | Aging & The Extracellular Matrix, Foresight Institute. Nov 10th 2022

    https://foresight.org/summary/collin-ewald-aging-the-extracellular-matrix/

    https://youtu.be/ohd3bwjySlU

     

    Collin Ewald presents at ARDD 2021: Extracellular matrix remodeling during longevity. https://youtu.be/dVnH7wKV3G4

     

    Podcasts on Spotify

    #69: Prof. Collin Ewald - Molecular Mechanisms of Healthy Ageing, Feb 26th 2022, Beginner's Mind

    https://open.spotify.com/episode/2OufIAYhBwUh8VYdGOF7sP

     

    #10 Dr. Collin Ewald, Collagen Protein & Extracellular Matrix during Aging- Jan 18th 2022, Live Longer World

    https://open.spotify.com/episode/6m0bR6EeogWVFr9uWzsXyB

     

    #008: Marc Bernegger, Tobias Reichmuth, Collin Ewald- April 8th 2021, The Longevity Biotech

    https://open.spotify.com/episode/2fWyKl5LlSQA7cqvGJK1FB​

  • ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

    Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell & Collin Y. Ewald

     

     

    End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

    eLife. 2021;10:e71335 DOI: 10.7554/eLife.71335​

    Richard Venz, Tina Pekec, Iskra Katic, Rafal Ciosk, Collin Yvès Ewald

     

    Strikingly, at geriatric ages, when 75% of the population had died, AID-mediated depletion of DAF-2 protein resulted in a doubling in lifespan. Thus, we provide a proof-of-concept that even close to the end of an individual’s lifespan, it is possible to slow aging and promote longevity.

    Youthful and age-related matreotypes predict drugs promoting longevity

    Aging Cell. 2021 Sep;20(9):e13441. doi: 10.1111/acel.13441. Epub 2021 Aug 4.

     

    Cyril Statzer , Elisabeth Jongsma , Sean X Liu, Alexander Dakhovnik, Franziska Wandrey , Pavlo Mozharovskyi, Fred Zülli, Collin Y Ewald

     

    Our innovative drug screening approach-employing extracellular matrix homeostasis-facilitates the discovery of pharmacological interventions promoting healthy aging.

    The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy Aging

    For full version, pls see preprint: doi: 10.20944/preprints201908.0063.v1

    https://www.preprints.org/manuscript/201908.0063/v1

     

    For anyone interested in joining our lab, pls read this paper.

    And/or watch this interview from Ira Pastor, ideaXme longevity and aging Ambassador and Founder of Bioquark:

    Superhighway of Our Cells: Extracellular Matrix With Prof Collin Ewald

    https://youtu.be/j8_6iBP6hqM

    Dauer-independent insulin/IGF-1 signalling implicates collagen remodelling in longevity.

    Ewald, C.Y., Landis, J.N., Porter Abate, J., Murphy, C.T., Blackwell, T.K. (2015).

     

    Media Coverage:

    Joslin News release video [link]

    Science Daily [link]

    MedicalXpress [link]

    The Scientist: Long Live Collagen [link]

    TV interview, 7vor7, TeleBasel, Switzerland [link]

    Radio interview, SWR2 (Südwestrundfunk) German Public Radio [link]

    Honoree mentioning from American Federation For Aging Research [link]

    Rated “Exceptional” at Faculty Opinions [link]

  • Funding

    Our science is supported by

    Competitive ETH Equipment Grant and ETH PhD Research Grant

    Novartis Foundation for medical-biological Research

    http://www.stiftungmedbiol.novartis.com

    Bridging high-throughput screens with automated lifespan machine to identify novel molecular targets that promote healthy ageing

    Dr. Wilhelm Hurka Stiftung Zürich

    COST EU Travel Award

  • Meet Our Team

    The Ewald Lab officially started on June 1st 2016.

    Principal Investigator

    PhD in Neuroscience, City University of New York, 2011

    Wikipedia

    ETH profile

    Career at a glance

    Worm Lineage

    CV

    LinkedIn

    ResearchGate

    Google Scholar

    Research ID: K-6303-2015

    ORCID: orcid.org/0000-0003-1166-4171

    Eline Jongsma

    PhD Student

    Master of Neurosciences, VU University Amsterdam

    Currently working on Master's thesis at ETH Zurich
    Internship at Netherlands Institute for Neurosciences

     

    Bachelor of Life Sciences, HAN university, Netherlands

    Thesis at Wageningen University, Laboratory of Nematology

    Internship at Dundee University, department of Gene Regulation and Expression

    Small collaboration project with Oxford University, department of Biochemistry

    Anita Goyala

    Postdoctoral Fellow

    PhD in Molecular Aging, National Institute of Immunology, New Delhi, India (2019)
    · M.Sc in Biomedical Sciences, ACBR, University of Delhi, New Delhi, India (2012)
    · B.Sc in Biomedical Sciences, BCAS, University od Delhi, New Delhi, India (2010)

    CV

    https://youtu.be/nbrS7cLnJYg

    Alex Dakhovnik

    Postdoctoral Fellow

    PhD in Molecular Biology, Friedrich-Schiller-Universität Jena, Germany (2021)

    Doctoral thesis work in Molecular Genetics, Universität zu Köln, Germany (2012-2015 terminated)
    M.Sc in Molecular Biology, Taras Shevchenko National University of Kyiv, Ukraine (2011)
    B.Sc in Biology (Department of Biochemistry), Taras Shevchenko National University of Kyiv, Ukraine (2009)

    CV

    Publications

    Alumni

    • 2022 Marie Knufinke (Master Thesis)
    • 2021 Pavlo Mozharovskyi (Guest Professor)
    • 2021 Felix Kempter (Medical Student)
    • 2021 Marco Ruckstuhl (Master Project)
    • 2016-20 Cyril Statzer (PhD Student)
    • 2016-20 Alina Teuscher (PhD Student)
    • 2017-20 Richard Venz (PhD Student)
    • 2019 Alex Hofer (Master Project)
    • 2019 Katharina Tarnutzer (Master Thesis)
    • 2019 Tugce Yenice (Master Project)
    • 2019 Victoria Brügger (Bachelor)
    • 2019 Sean X. Liu (AMGEN scholar)
    • 2019 Anastasiia Korosteleva (AMGEN scholar)
    • 2019 Andrea Thurnheer (Internship)
    • 2018 Vira Chea (Master Project)
    • 2018 Alex Baillifard (Master Thesis)
    • 2018 Julia Kan (Internship, Medical Student)
    • 2018 Cosmina-Maria Matioc (Amgen Scholar)
    • 2018 Özgen Eren (Master Thesis; together with IBM Research Zürich)
    • 2018 Surya Häne (Master Project)
    • 2017 Seraina Domenig (Master Thesis, nominated for ETH medal)
    • 2017 Max Hess (Master Thesis)
    • 2017 Anna Bircher (Master Thesis)
    • 2017 Yannik Trabesinger (Maturaarbeit: «Ein Schlüssel zur Unsterblichkeit - Rejuvenation mit C. elegans». Recognized with appraisal of excellence from Kantonsschule Wattwil)
    • 2017 Özlem Altintas (Internship)
    • 2017 Kieran Toms (Amgen Scholar/Medical Student)
    • 2017 Mariam Baghdady (Bachelor Thesis)
    • 2017 Nadine Herrmann (Internship)
    • 2017 Kateryna Selcuk (Master project)
    • 2017 Julia Bertschinger (Maturaarbeit)
    • 2017 Cindy Somsak (Maturaarbeit)
  • Ewald Lab news

    Excited to teach my own designed course this fall semester about "Translation of Basic Research Findings from Genetics and Molecular Mechanisms of Aging." @ETHhttp://www.vvz.ethz.ch/Vorlesungsverzeichnis/lerneinheitPre.do?lerneinheitId=118385&semkez=2017W&lang=de

  • Social Feed

    Check out our latest updates!

  • Job Opportunities

    We are looking for highly motivated scientists with great enthusiasm for aging research and the ability to creatively solve problems.

    Current available positions in our lab @ ETH Zürich

    There are 3 master projects available only for ETH students. See below for details.

    There are no available positions for: internships, Maturaarbeits, bachelors.

    Master Thesis in our lab @ ETH Zürich

    Important the successful applicant must be in the master's program at ETH.

     

    1. Master thesis: How 2 neurones control longevity through dietary restriction. Previously, 2 neurons have been shown to be required for organismal longevity under dietary restriction via the transcription factor SKN-1 in C. elegans doi:10.1038/nature05904. However, the mechanism how these neurons communicate with the peripheral tissue to improve health during aging is unknown. The master student will implement neuronal-specific DAM-ID to determine SKN-1 downstream target genes. This will generate hypothesis of the signalling molecule from the neurones to the peripheral tissue. Candidate genes will be assessed for their requirement with the lifespan assays.

     

    2. Master thesis: Wound healing during aging in C. elegans. Wound healing might decline with aging and is impaired in diabetic patients. Assessing wound healing capacity of aging C. elegans. Measure the effects of aging and identify molecular mechanisms to improve wound healing during aging. The candidate will optimize and further develop currently used wound assessment for C. elegans. Please, see https://www.jove.com/video/51959/methods-for-skin-wounding-and-assays-for-wound-responses-in-c-elegans.

     

    3. Master project on viscoelastic properties of aging C. elegans. Glycation and Advanced glycation end products are major complication of diabetic patients and the elderly population. The overall goal is to re-built the "bending device" described in this paper doi: 10.1073/pnas.1219965110 with the remote help of the authors of this paper. Then test bending stiffness of aging C. elegans and identify mechanisms to prevent stiffening of collagens. These mechanisms might be conserved in mammals helping to identify novel strategies against age-dependent glycation or collagen crosslinking as seen in diabetes patients.


    Contact Details
    Please, send CV, a paragraph explaining your motivation working on this project and highlighting your skills. Please, email at collin-ewald(at)ethz.ch

    Fellowship opportunities for prospective post docs

    In general, we are always looking for creative minds. Below is a list of fellowship opportunities.

     

    ETH Zurich Postdoctoral Fellowships (ETH Fellows)

    Submission deadlines are March 1 and September 1.

    https://www.ethz.ch/en/research/research-promotion/eth-internal-programmes/eth-fellowships.html

     

    EMBO Long-Term Fellowships

    NOTICE: Applications are now accepted throughout the year.

    http://embo.org/funding-awards/fellowships/long-term-fellowships#about

     

    IBSA FOUNDATION

    funds each year several young researchers to promote and facilitate the realization of their postdoctoral traineeships with
    12 month fellowships of € 24,000.00 in ve research fields

    http://www.ibsafoundation.org/fellowships.html

    Deadline: Dec 31st 2016

    http://www.ibsafoundation.org/borse_studio/fellowship2016.pdf

     

    FEBS Fellowships

    http://www.febs.org/our-activities/fellowships/

     

    Human Frontier Science Program

    HFSP fellowships are for three years. Fellows may choose to stay for up to three years in the host country or use the last year of their fellowship to return to their home country or to move to another HFSPO member country.

    The next fellowship competition will be in August 2017.

    http://www.hfsp.org/funding/postdoctoral-fellowships

     

    AXA Research Fund Post-Doctoral Fellowships

    In 2017 the AXA Research Fund will be proposing up to 25 Post-Doctoral Fellowships to outstanding researchers. You can be awarded a grant for up to €130,000 for an 18 to 24 month period.

    https://www.axa-research.org/en/page/post-doctoral-fellowships

     

    Stiftung Prof. Dr. Max Cloëtta

    http://www.cloetta-foundation.ch/de/forschungsstellen/

     

    MARIE SKŁODOWSKA-CURIE INDIVIDUAL FELLOWSHIPS

    http://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/msca-if-2017.html​

     

    Swiss Government Excellence Scholarships for Foreign Scholars

    https://www.sbfi.admin.ch/sbfi/en/home/topics/swiss-education-area/scholarships-and-grants/swiss-government-excellence-scholarships-for-foreign-scholars-an.html

    Fellowship opportunities for prospective PhD students

    In general, we are always looking for creative minds. Below is a list of fellowship opportunities.

     

    Boehringer Ingelheim Fonds PhD fellowships

    Deadlines of application: 1 February, 1 June, 1 October of each year.

    https://www.bifonds.de/fellowships-grants/phd-fellowships.html

     

    Erasmus Mundus Programme

    http://eacea.ec.europa.eu/erasmus_mundus/funding/scholarships_students_academics_en.php#1

     

    Swiss Government Excellence Scholarships for Foreign Scholars

    https://www.sbfi.admin.ch/sbfi/en/home/topics/swiss-education-area/scholarships-and-grants/swiss-government-excellence-scholarships-for-foreign-scholars-an.html

  • Drop Us A Note

    Don't be afraid to reach out.

  • Lab Information

    The Extracellular Matrix Regeneration Laboratory of Professor Dr. Collin Y. Ewald

    Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich
    SLA C 8
    Schorenstrasse 16
    8603 Schwerzenbach-Zürich
    Schweiz

    Google maps just type in "Ewald Lab".

    To find out more about ETH, click here.

  • Misc

    Check out our YouTube channel: EwaldLab ETHZ

     

    Ewald Lab Logo designed by Felix Marbet: http://felixmarbet.strikingly.com​

     

    Swiss Society for Aging Research

    We are members of the Swiss Society for Aging Research (SSFAR)

    Swiss Society for Matrix Biology

    We are members of the Swiss Society for Matrix Biology (ssmb)

    GENiE Member

    We are a member of the GENiE network that connects young research labs across Europe that work with the model organism C. elegans. Link to our GENiE profile.

    ETH Zurich and the University of Zurich Life Science Zurich Graduate School

    We are a member of the Molecular Life Science PhD program at the ETH Zurich and the University of Zurich Life Science Zurich Graduate School.

    Productivity Tools

    C. elegans: The New Generation By Greg Nelson Worm Breeder's Gazette Volume 18, Number 1 December 2009

    Recommended Reading

    C. elegans

    Sydney Brenner (1974) The Genetics of Caenorhabditis elegans.

     

    Corsi, A.K., et al. 2015. A Transparent Window into Biology: A Primer on Caenorhabditis elegans. Genetics. 2015 Jun;200(2):387-407. doi: 10.1534/genetics.115.176099.

     

    Jorgensen, E.M. & Mango, S.E., 2002. The art and design of genetic screens: Caenorhabditis elegans. Nature Reviews Genetics, 3(5), pp.356–369.

     

     

    Aging Research

    Kenyon, C.J. et al., 1993. A C. elegans mutant that lives twice as long as wild type. Nature, 366(6454), pp.461–464.

     

    Herndon, L.A. et. al., 2002. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature. 24;419(6909):808-14.

     

    Gidalevitz, T. et al., 2006. Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science (New York, NY), 311(5766), pp.1471–1474.

     

    Kenyon, C.J., 2010. The genetics of ageing. Nature, 464(7288), pp.504–512.

     

    López-Otín, C. et al., 2013. The hallmarks of aging. Cell, 153(6), pp.1194–1217.

     

    Taylor, R.C. et al., 2014. Systemic stress signalling: understanding the cell non-autonomous control of proteostasis. Nature Reviews Molecular Cell Biology, 15(3), pp.211–217.

     

    Mannick, J.B. et al., 2014. mTOR inhibition improves immune function in the elderly. Science translational medicine, 6(268), pp.268ra179–268ra179.

     

    Scott, C.T., 2015. Selling long life. Nat Biotechnol. 2015 Jan;33(1):31-40. doi: 10.1038/nbt.3108.

     

     

    Advice for young researchers

    Kahn, C.R., 1994. Picking a research problem. The critical decision. The New England journal of medicine, 330(21), pp.1530–1533.

     

    Alon, U., 2009. How to choose a good scientific problem. Molecular cell, 35(6), pp.726–728.

     

    Yanai, I., Lercher, M. What is the question?. Genome Biol 20, 289 (2019) doi:10.1186/s13059-019-1902-1

     

    Lindquist, S., 2010. Three quite different things that matter to me. Molecular biology of the cell, 21(22), pp.3804–3804.

     

    Martin Chalfie. 2014. The Secret to Getting the Postdoc You Want

     

    Peter Walter: On Careers and 42

     

    Richard Axel. 2018, Neuron, 99(6), pp.1110–1112. DOI:https://doi.org/10.1016/j.neuron.2018.09.003

     

    van Dijk, D., Manor, O. & Carey, L.B., 2014. Publication metrics and success on the academic job market. Current biology : CB, 24(11), pp.R516–7.

     

    Night science. Itai Yanai & Martin Lercher
    Genome Biology volume 20, Article number: 179 (2019)

     

    Writing tips

    Mensh, B. & Kording, K., 2017. Ten simple rules for structuring papers. PLoS Computational Biology, 13(9), p.e1005619.

     

    Marder, E., 2019. Love writing. eLife, 8:e45734 DOI: 10.7554/eLife.45734

     

    https://www.elsevier.com/connect/six-things-to-do-before-writing-your-manuscript

    https://www.elsevier.com/connect/11-steps-to-structuring-a-science-paper-editors-will-take-seriously

     

    https://www.nature.com/scitable/ebooks/english-communication-for-scientists-14053993/118519636#bookContentViewAreaDivID

     

    Novelist Cormac McCarthy’s tips on how to write a great science paper

    Hide Editor Panel. https://www.nature.com/articles/d41586-019-02918-5

     

     

    Beautifully presented papers

    Yip, Z.C. & Heiman, M.G., 2016. Duplication of a Single Neuron in C. elegans Reveals a Pathway for Dendrite Tiling by Mutual Repulsion. Cell reports, 15(10), pp.2109–2117.

     

     

    Additional Resources:

    The Elements of Style by William Strunk, Jr.

    WormAtlas

    WormBook

    C. elegans II, 2nd edition

    The Worm Breeder's Gazette

    WormBase

    WormClassroom

    ApE- A plasmid Editor

    The illustrated guide to a Ph.D.

    Is It Real? Can We Win? Is It Worth Doing?: Managing Risk and Reward in an Innovation Portfolio

    Recommended Video

    Extracellular matrix

    Cell–Extracellular Matrix Mechanobiology

    https://youtu.be/LajvidhBK2Y

     

    C. elegans

    For scientist joining my lab, we use wormbase.org on a daily bases.. hence, watch this.

    http://blog.wormbase.org/2019/08/02/wormbase-workshop-talks-at-the-2019-iwm-available-on-youtube/

     

    Recommended Nobel lectures

    Sydney Brenner

    https://www.nobelprize.org/prizes/medicine/2002/brenner/lecture/

    H. Robert Horvitz

    https://www.nobelprize.org/prizes/medicine/2002/horvitz/lecture/

    Marty Chalfie

    https://www.nobelprize.org/prizes/chemistry/2008/chalfie/lecture/

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