Our Mission was
Our aim was to determine the molecular mechanism(s) that prolong health during aging, using systems level approaches on human biology, omics, machine learning, C. elegans and mice, in order to develop novel clinical strategies to treat age-related pathologies.
By 2030 almost every fourth person will be 65 or older in Switzerland, Europe, and USA. Since old age is the main risk factor for developing cancer, neurodegenerative, cardiovascular, and metabolic diseases, as well as other age-related pathologies, the growing elderly population poses an immense social and financial challenge. [read more] [pdf]
To identify novel strategies to improve human healthspan.
Using C. elegans as a pioneering system to model the aging process because of its ease for genetic manipulation, high evolutionary conservation of genes implicated in human diseases, and short lifespan (3 weeks). Importantly, using C. elegans lifespan assays as a read-out for extension of healthspan is a tractable and fast approach for discovering novel mechanisms that confer healthy aging. Several fundamental mechanisms discovered in C. elegans have been shown to delay age-related pathologies in higher organisms, such as mice, and these mechanisms have major implications for humans aging. Hence, by using C. elegans to model the aging process we could rapidly identify strategies to improve human healthspan.
The lab focused on exploring a novel and exciting mechanism that promotes healthy aging.
Our recent work has shown that many health- and longevity-promoting interventions re-activate the expression of extracellular matrix (ECM) genes during aging (Ewald et al., Nature 2015, PMID:25517099). This ECM enhancement is required and sufficient for extending the lifespan of C. elegans. Our research efforts are focusing on exploring the mechanism(s) of how prolonged ECM homeostasis promotes healthy aging. [read more] [pdf]
Our core competencies are:
Our technical expertise with using the model organism C. elegans are:
Ziel der Forschungsgruppe war es...
Lay summary in German
Kapitelauszug über unsere Forschung geschrieben von Alejandra Garcia Lanz (Schülerin der Gewerblich-Industrielle Berufsschule Bern; Vertiefungsarbeit ABU, 7.3.2019)
Wenn Sie mehr wissen wollen, meine Einführungsvorlesung an der ETH Zürich gibt eine gute Übersicht über unsere Forschung.
Auf den Link klicken und die Vorlesung: "Molekulare Mechanismen des gesunden Alterns (Collin Ewald)" kommen.
Kann man das Altern verlangsamen? Fadenwürmer im Fokus der Altersforschung. EwaldLab Interview by Patrick Bardelli Galaxus Hintergrund, Sport, Gesundheit. 12.05.2022
Labor Journal: Nur nicht bescheiden sein. 12.05.2022
Life Science Get2Gether #LSG2G by #ChristianSoschner
Episode #69: Prof. Collin Ewald - Molecular Mechanisms of Healthy Ageing
Feb 26th 2022
#Age is just a number. Flipping a genetic switch, even at #old age, can #rejuvenate #elderly worms. Episode 78. January 2022. Start 30min. Interviewed by @DrChrisSmith @nakedscientists.
Live Longer World interview: Dr. Collin Ewald | Collagen Protein & Extracellular Matrix During Aging. January 18th 2022
Longevity Technology (#Innovation): Increased lifespan? Make mine a double!
October 29, 2021
Mindset 2021: Bernegger, Marc P.; Gushchina, Julia; Branford, Jason; Rochel, Johan. 30.09.2021
Mentioning Ewald Lab at 34min 29sec.
«Covidisierung» der Forschung verzögert andere Projekte: Echo der Zeit @SRF2 10.01.2021
Danke für den schön geschrieben Artikel von Alexandra Bröhm @sonntagszeitung und das Interview mit mir über #Gesund ins hohe #Alter- wie Joe Biden. #healthy #aging #extrazelluläreMatrix #ewaldlab @ETH.
Ein Altersforscher in Zürich erprobt am Fadenwurm, welche Gene unsere Zellen altern lassen und was Anti-Aging-Medikamente bewirken.
BR Fernsehen Gut zu wissen | Wissensmagazin. 21.03.2020, 19:00 Uhr.
Fast-forward to minute 21.
(Also broadcasted by Arte, Wissenschaft, Xenius: Alternsforschung. Our part after 3 min: https://www.arte.tv/de/videos/092139-033-A/xenius-altersforschung/)
Superhighway Of Our Cells: Extracellular Matrix with Prof. Collin Ewald- Ira Pastor, ideaXme longevity and aging ambassador and Founder of Bioquark, interviews Prof. Dr. Collin Ewald, Department of Health Sciences and Technology, at ETH Zurich (The Swiss Federal Institute of Technology in Zurich), Founder of Swiss Society for Aging Research and Vice President Swiss Society for Matrix Biology.
Alumni Spotlight Graduate Center of the City University of New York
Time: As long as you live. TVB News (Hong Kong)
See starting after 1:34 and 2:28. #EwaldLab
Who is Who in Medical Research: A compendium of Hochschulmedizin Zurich (1st edition 2017) compiles all the information of nearly 200 research groups at the level of professorships relevant for collaboration in the medical field.
Ep. 3 - Prof. Collin Ewald talks getting old and feeling young - Part 1 | Simplifyd
Ep. 3 - Prof. Collin Ewald talks the cost of Alzheimer's and "mega cancer"- Part 2 | Simplifyd
An almost forgotten pioneer - UNI NOVA
ETH/EPFL Influencer World Ranking
Collin Ewald (@CollinEwald) (Ranked 16th, 30.09.20)
Current Research from the Ewald Lab
If you want to see the latest research coming out of the Ewald lab.
Collin Ewald | Aging & The Extracellular Matrix, Foresight Institute. Nov 10th 2022
Collin Ewald presents at ARDD 2021: Extracellular matrix remodeling during longevity. https://youtu.be/dVnH7wKV3G4
Podcasts on Spotify
#69: Prof. Collin Ewald - Molecular Mechanisms of Healthy Ageing, Feb 26th 2022, Beginner's Mind
#10 Dr. Collin Ewald, Collagen Protein & Extracellular Matrix during Aging- Jan 18th 2022, Live Longer World
#008: Marc Bernegger, Tobias Reichmuth, Collin Ewald- April 8th 2021, The Longevity Biotech
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell & Collin Y. Ewald
Longevity interventions temporally scale healthspan in Caenorhabditis elegans
End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies
Richard Venz, Tina Pekec, Iskra Katic, Rafal Ciosk, Collin Yvès Ewald
Strikingly, at geriatric ages, when 75% of the population had died, AID-mediated depletion of DAF-2 protein resulted in a doubling in lifespan. Thus, we provide a proof-of-concept that even close to the end of an individual’s lifespan, it is possible to slow aging and promote longevity.
Youthful and age-related matreotypes predict drugs promoting longevity
Cyril Statzer , Elisabeth Jongsma , Sean X Liu, Alexander Dakhovnik, Franziska Wandrey , Pavlo Mozharovskyi, Fred Zülli, Collin Y Ewald
Our innovative drug screening approach-employing extracellular matrix homeostasis-facilitates the discovery of pharmacological interventions promoting healthy aging.
The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy Aging
For full version, pls see preprint: doi: 10.20944/preprints201908.0063.v1
For anyone interested in joining our lab, pls read this paper.
And/or watch this interview from Ira Pastor, ideaXme longevity and aging Ambassador and Founder of Bioquark:Superhighway of Our Cells: Extracellular Matrix With Prof Collin Ewald
Dauer-independent insulin/IGF-1 signalling implicates collagen remodelling in longevity.
Ewald, C.Y., Landis, J.N., Porter Abate, J., Murphy, C.T., Blackwell, T.K. (2015).
Joslin News release video [link]
Science Daily [link]
The Scientist: Long Live Collagen [link]
TV interview, 7vor7, TeleBasel, Switzerland [link]
Radio interview, SWR2 (Südwestrundfunk) German Public Radio [link]
Honoree mentioning from American Federation For Aging Research [link]
Rated “Exceptional” at Faculty Opinions [link]
Our science was supported by
Competitive ETH Equipment Grant and ETH PhD Research Grant
Novartis Foundation for medical-biological Research
Bridging high-throughput screens with automated lifespan machine to identify novel molecular targets that promote healthy ageing
Dr. Wilhelm Hurka Stiftung Zürich
Meet Our Team
The Ewald Lab officially started on June 1st 2016 and closed May 31st 2023.
Advice for young researchers
Beautifully presented papers
Cell–Extracellular Matrix Mechanobiology
For scientist joining my lab, we use wormbase.org on a daily bases.. hence, watch this.
Recommended Nobel lectures
H. Robert Horvitz