Reduced Insulin/IGF-1 signaling (rIIS) increases lifespan in the nematode Caenorhabditis elegans, flies, and mice. This signaling pathway is the most studied longevity intervention in C. elegans. However, rIIS pathway also regulates a developmental arrest stage that can be activated improperly during adulthood. In the benchling.org article, we discuss methods to avoid dauer-associated effects on longevity.
Studying how to prolong a worm’s life? @CollinEwald shares with Benchling two new ways to control for dauer:
A special thanks to the Benchling team.